The focus is increasingly on mesenchymal stem cells (MSCs) derived from human adipose tissue due to their abundance and ease of access. These multipotent cells can differentiate into mature adipocytes, as well as chondrocytes, osteoblasts, myocytes, and other cell lineages, as suggested by in vitro, ex vivo and in vivo tests, and this potential can be used to regenerate damaged tissues. In addition, mesenchymal stem cells secrete a wide variety of bioactive molecules that act in a paracrine form to nourish, stimulate and sustain angiogenic (blood vessel formation), antifibrotic, antiapoptotic (slowing cell death) and immunomodulatory responses in the target tissue over which they are used.
The urgent need to find new therapies for chronic immunological and degenerative diseases has led many researchers to look for products that contain progenitor cells while avoiding the problems and restrictions related to enzymatic manipulation and cell expansion in accordance with good practices of manufacturing (GMP standards).
The availability of minimally manipulated products based on an adequate content of stem cells has resulted in shorter procedure times and the ability to apply autologous grafts in a one-step intervention. Lipogems® technology guarantees these two requirements in a fast, easy-to-use disposable adipose tissue transfer device and represents a very promising approach.
The innovative technique Lipogems is used by our doctors at Harley Street Hospital, it allows to obtain micro fragmented adipose tissue with an intact stromal vascular niche and mesenchymal stem cells with a high regenerative capacity. This is easy to use a system designed to collect, process and inject refined fat tissue and is characterized by its optimal handling capacity and a great regenerative potential based on fat-derived stem cells. In this technology, the adipose tissue is washed, emulsified and rinsed and the dimensions of the adipose grain are gradually reduced to a range of about 0.3 to 0.8 mm.
Lipogems® has been used in more than 10,000 patients around the world in aesthetic medicine and surgery, as well as in orthopedic surgery and general surgery, with good results and apparently without problems. To date, there are already several clinical trials with satisfactory results.
